Esomeprazole
(Redirected from Nexium)
| Drug monograph · NCLEX study reference | |
| Trade names | Nexium |
|---|---|
| Therapeutic class | Antiulcer, antisecretory |
| Pharmacologic class | Proton pump inhibitor |
| Onset / peak / duration | Onset about 1 hour; sustained. |
| Half-life / level | Half-life 1 to 1.5 hours with long effect. |
| Routes | PO (oral), IV |
| High-alert (ISMP) | No |
| Black box warning | None |
| Antidote / reversal | Not applicable. |
| Pregnancy / lactation | Use if needed. |
Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and must be verified against current manufacturer labeling before clinical use. This is educational content, not prescribing guidance.
Esomeprazole (brand name Nexium) — Antiulcer, antisecretory; Proton pump inhibitor.
Identification
- Therapeutic class: Antiulcer, antisecretory.
- Pharmacologic class: Proton pump inhibitor.
Pharmacology
- Mechanism of action: S-isomer of omeprazole; same proton pump blockade.
- Onset / peak / duration: Onset about 1 hour; sustained.
- Half-life / therapeutic level: Half-life 1 to 1.5 hours with long effect.
Clinical use
- Indications: GERD, erosive esophagitis, H. pylori, ulcer prophylaxis with NSAIDs.
- Usual dose, route, frequency: 20 to 40 mg PO daily; IV available.
- Maximum dose / adjustments: Reduce in severe hepatic impairment.
Safety
- Contraindications: Use with rilpivirine, hypersensitivity.
- Black box warning: None.
- Interactions: Same as omeprazole (clopidogrel, acid-dependent drugs).
- Pregnancy / lactation: Use if needed.
- High-alert: No.
Adverse effects
- Common side effects: Headache, diarrhea, nausea.
- Serious effects to report: C. difficile, hypomagnesemia, interstitial nephritis.
- Antidote / reversal: Not applicable.
Nursing process
- Assessment before administration: Symptoms, magnesium with long use.
- Interventions during therapy: Give before a meal.
- Monitor: Symptom relief, magnesium with long use.
- Evaluation / expected outcome: Reduced reflux and healing.
Patient teaching
- Patient teaching: Take before eating; swallow whole or open capsule onto applesauce.
- Notify provider if: Persistent diarrhea, cramps, ongoing symptoms.
- Administration tips: Before meals.