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Methimazole - Revision history
2026-06-17T18:11:08Z
Revision history for this page on the wiki
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Docmoates: Add medication infobox (Drugbox) to monographs
2026-06-17T16:09:33Z
<p>Add medication infobox (Drugbox) to monographs</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:09, 17 June 2026</td>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| name = Methimazole</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| brand = Tapazole</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| therapeutic = Antithyroid</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| pharmacologic = Thioamide</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| onset = Effect over 1 to 3 weeks as stored hormone depletes.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| halflife = Half-life 4 to 6 hours; monitor thyroid labs.</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| antidote = None; discontinue.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">| pregnancy = Avoid in the first trimester; can be used later.</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.''</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.''</div></td></tr>
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https://wiki.docmoates.com/index.php?title=Methimazole&diff=4490&oldid=prev
Docmoates: NCLEX nursing pharmacology monographs — batch import
2026-06-17T14:06:11Z
<p>NCLEX nursing pharmacology monographs — batch import</p>
<p><b>New page</b></p><div><div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"><br />
''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.''<br />
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<br />
'''Methimazole''' (brand name Tapazole) &mdash; Antithyroid; Thioamide.<br />
<br />
== Identification ==<br />
* '''Therapeutic class:''' Antithyroid.<br />
* '''Pharmacologic class:''' Thioamide.<br />
<br />
== Pharmacology ==<br />
* '''Mechanism of action:''' Inhibits thyroid hormone synthesis by blocking iodine organification.<br />
* '''Onset / peak / duration:''' Effect over 1 to 3 weeks as stored hormone depletes.<br />
* '''Half-life / therapeutic level:''' Half-life 4 to 6 hours; monitor thyroid labs.<br />
<br />
== Clinical use ==<br />
* '''Indications:''' Hyperthyroidism, Graves disease, preoperative preparation.<br />
* '''Usual dose, route, frequency:''' 5 to 40 mg PO daily.<br />
* '''Maximum dose / adjustments:''' Titrate to thyroid labs.<br />
<br />
== Safety ==<br />
* '''Contraindications:''' First-trimester pregnancy (PTU preferred then), known agranulocytosis with thioamides.<br />
* '''Black box warning:''' None.<br />
* '''Interactions:''' Warfarin, digoxin, beta blockers, theophylline (levels change as thyroid status normalizes).<br />
* '''Pregnancy / lactation:''' Avoid in the first trimester; can be used later.<br />
* '''High-alert:''' No.<br />
<br />
== Adverse effects ==<br />
* '''Common side effects:''' Rash, GI upset, arthralgia.<br />
* '''Serious effects to report:''' Agranulocytosis (fever, sore throat), hepatotoxicity.<br />
* '''Antidote / reversal:''' None; discontinue.<br />
<br />
== Nursing process ==<br />
* '''Assessment before administration:''' Thyroid labs, baseline CBC and LFTs.<br />
* '''Interventions during therapy:''' Teach to report fever or sore throat promptly.<br />
* '''Monitor:''' Thyroid labs, CBC, LFTs.<br />
* '''Evaluation / expected outcome:''' Normalized thyroid function.<br />
<br />
== Patient teaching ==<br />
* '''Patient teaching:''' Report any sign of infection immediately.<br />
* '''Notify provider if:''' Fever, sore throat, yellowing of skin, easy bruising.<br />
* '''Administration tips:''' Consistent daily timing.<br />
<br />
[[Category:Thyroid and Antithyroid Agents]]</div>
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