Docmoates: Add medication infobox (Drugbox) to monographs

2026-06-17T16:09:37Z

Add medication infobox (Drugbox) to monographs

← Older revision		Revision as of 16:09, 17 June 2026
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			{{Drugbox
			\| name = PDE-5 inhibitors
			\| brand = Viagra, Revatio, Cialis, Adcirca
			\| therapeutic = Erectile dysfunction agent, pulmonary hypertension agent, benign prostatic hyperplasia (tadalafil)
			\| pharmacologic = Phosphodiesterase-5 inhibitors
			\| onset = Sildenafil onset 30 to 60 minutes; tadalafil longer acting (up to 36 hours).
			\| halflife = Sildenafil about 4 hours, tadalafil about 17.5 hours; no routine level.
			\| routes = PO (oral)
			\| highalert = No
			\| blackbox = None
			\| antidote = Supportive care.
			\| pregnancy = Pulmonary hypertension use case by case.
			}}

	<div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;">		<div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;">
	''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.''		''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.''

Docmoates: NCLEX nursing pharmacology monographs — batch import

2026-06-17T14:06:22Z

NCLEX nursing pharmacology monographs — batch import

New page

<div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;">
''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.''
</div>

'''PDE-5 inhibitors''' (brand names Viagra, Revatio, Cialis, Adcirca) — Erectile dysfunction agent, pulmonary hypertension agent, benign prostatic hyperplasia (tadalafil); Phosphodiesterase-5 inhibitors.

== Identification ==
* '''Therapeutic class:''' Erectile dysfunction agent, pulmonary hypertension agent, benign prostatic hyperplasia (tadalafil).
* '''Pharmacologic class:''' Phosphodiesterase-5 inhibitors.

== Pharmacology ==
* '''Mechanism of action:''' Inhibit PDE-5 to enhance nitric oxide-mediated vasodilation in the penis and pulmonary vasculature.
* '''Onset / peak / duration:''' Sildenafil onset 30 to 60 minutes; tadalafil longer acting (up to 36 hours).
* '''Half-life / therapeutic level:''' Sildenafil about 4 hours, tadalafil about 17.5 hours; no routine level.

== Clinical use ==
* '''Indications:''' Erectile dysfunction, pulmonary arterial hypertension, benign prostatic hyperplasia (tadalafil).
* '''Usual dose, route, frequency:''' PO as needed before activity (erectile dysfunction) or daily (pulmonary hypertension, BPH).
* '''Maximum dose / adjustments:''' Reduce with strong CYP3A4 inhibitors and in hepatic or renal impairment; lower doses with alpha blockers.

== Safety ==
* '''Contraindications:''' Concurrent nitrates in any form, recent severe cardiovascular event, severe hypotension.
* '''Black box warning:''' None.
* '''Interactions:''' Nitrates (life-threatening hypotension, absolute contraindication), alpha blockers (hypotension), CYP3A4 inhibitors, riociguat.
* '''Pregnancy / lactation:''' Pulmonary hypertension use case by case.
* '''High-alert:''' No.

== Adverse effects ==
* '''Common side effects:''' Headache, flushing, nasal congestion, dyspepsia, visual color changes.
* '''Serious effects to report:''' Priapism (erection over 4 hours, an emergency), sudden vision loss (NAION), sudden hearing loss, severe hypotension.
* '''Antidote / reversal:''' Supportive care.

== Nursing process ==
* '''Assessment before administration:''' Cardiovascular status, nitrate use, blood pressure.
* '''Interventions during therapy:''' Confirm no nitrate use; counsel on priapism.
* '''Monitor:''' Blood pressure, response, vision and hearing changes.
* '''Evaluation / expected outcome:''' Improved erectile function or pulmonary pressures.

== Patient teaching ==
* '''Patient teaching:''' Never combine with nitrates or recreational nitrites (poppers); seek emergency care for an erection lasting over 4 hours or sudden vision or hearing loss.
* '''Notify provider if:''' Erection over 4 hours, sudden vision or hearing change, chest pain.
* '''Administration tips:''' Take before activity (erectile dysfunction); avoid high-fat meals with sildenafil (delays onset).

[[Category:Erectile Dysfunction and Pulmonary Hypertension]]

PDE-5 inhibitors - Revision history

Docmoates: Add medication infobox (Drugbox) to monographs

Docmoates: NCLEX nursing pharmacology monographs — batch import