Pravastatin: Difference between revisions
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NCLEX nursing pharmacology monographs — batch import |
Add medication infobox (Drugbox) to monographs |
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{{Drugbox | |||
| name = Pravastatin | |||
| brand = Pravachol | |||
| therapeutic = Antihyperlipidemic | |||
| pharmacologic = Statin | |||
| onset = Onset about 1 to 2 weeks; peak 4 weeks. | |||
| halflife = Half-life about 2 to 3 hours; no routine level. | |||
| routes = PO (oral) | |||
| highalert = No | |||
| blackbox = None | |||
| antidote = None. | |||
| pregnancy = Contraindicated. | |||
}} | |||
<div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"> | <div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"> | ||
''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.'' | ''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.'' | ||
Latest revision as of 16:09, 17 June 2026
| Drug monograph · NCLEX study reference | |
| Trade names | Pravachol |
|---|---|
| Therapeutic class | Antihyperlipidemic |
| Pharmacologic class | Statin |
| Onset / peak / duration | Onset about 1 to 2 weeks; peak 4 weeks. |
| Half-life / level | Half-life about 2 to 3 hours; no routine level. |
| Routes | PO (oral) |
| High-alert (ISMP) | No |
| Black box warning | None |
| Antidote / reversal | None. |
| Pregnancy / lactation | Contraindicated. |
Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and must be verified against current manufacturer labeling before clinical use. This is educational content, not prescribing guidance.
Pravastatin (brand name Pravachol) — Antihyperlipidemic; Statin.
Identification
- Therapeutic class: Antihyperlipidemic.
- Pharmacologic class: Statin.
Pharmacology
- Mechanism of action: Same statin mechanism; not metabolized by CYP3A4, so fewer interactions.
- Onset / peak / duration: Onset about 1 to 2 weeks; peak 4 weeks.
- Half-life / therapeutic level: Half-life about 2 to 3 hours; no routine level.
Clinical use
- Indications: Hyperlipidemia, cardiovascular prevention.
- Usual dose, route, frequency: 10 to 80 mg PO once daily.
- Maximum dose / adjustments: Max 80 mg/day; start low in significant renal/hepatic impairment.
Safety
- Contraindications: Active liver disease, pregnancy, lactation.
- Black box warning: None.
- Interactions: Fewer than other statins; fibrates and cyclosporine increase myopathy risk; red yeast rice.
- Pregnancy / lactation: Contraindicated.
- High-alert: No.
Adverse effects
- Common side effects: Myalgia, headache, GI upset.
- Serious effects to report: Rhabdomyolysis, hepatotoxicity.
- Antidote / reversal: None.
Nursing process
- Assessment before administration: Lipids, LFTs, pregnancy status.
- Interventions during therapy: May give without regard to meals or grapefruit.
- Monitor: Lipids, LFTs, CK if symptomatic.
- Evaluation / expected outcome: LDL at goal.
Patient teaching
- Patient teaching: Often chosen when interactions are a concern.
- Notify provider if: Muscle pain, dark urine, jaundice.
- Administration tips: Any time daily; food not required.