Propylthiouracil: Difference between revisions
Jump to navigation
Jump to search
NCLEX nursing pharmacology monographs — batch import |
Add medication infobox (Drugbox) to monographs |
||
| Line 1: | Line 1: | ||
{{Drugbox | |||
| name = Propylthiouracil | |||
| brand = PTU | |||
| therapeutic = Antithyroid | |||
| pharmacologic = Thioamide | |||
| onset = Effect over weeks. | |||
| halflife = Half-life 1 to 2 hours; monitor thyroid labs. | |||
| routes = PO (oral) | |||
| highalert = No | |||
| blackbox = <span style="color:#b00020;">'''Yes'''</span> (see Safety) | |||
| antidote = None; discontinue. | |||
| pregnancy = Preferred antithyroid in the first trimester. | |||
}} | |||
<div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"> | <div style="border-left:4px solid #3f6f5b;background:#f3f6f4;padding:8px 12px;margin-bottom:12px;font-size:0.95em;"> | ||
''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.'' | ''Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and '''must be verified against current manufacturer labeling before clinical use'''. This is educational content, not prescribing guidance.'' | ||
Latest revision as of 16:09, 17 June 2026
| Drug monograph · NCLEX study reference | |
| Trade names | PTU |
|---|---|
| Therapeutic class | Antithyroid |
| Pharmacologic class | Thioamide |
| Onset / peak / duration | Effect over weeks. |
| Half-life / level | Half-life 1 to 2 hours; monitor thyroid labs. |
| Routes | PO (oral) |
| High-alert (ISMP) | No |
| Black box warning | Yes (see Safety) |
| Antidote / reversal | None; discontinue. |
| Pregnancy / lactation | Preferred antithyroid in the first trimester. |
Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and must be verified against current manufacturer labeling before clinical use. This is educational content, not prescribing guidance.
Propylthiouracil (brand name PTU) — Antithyroid; Thioamide.
Identification
- Therapeutic class: Antithyroid.
- Pharmacologic class: Thioamide.
Pharmacology
- Mechanism of action: Blocks thyroid hormone synthesis and peripheral T4-to-T3 conversion.
- Onset / peak / duration: Effect over weeks.
- Half-life / therapeutic level: Half-life 1 to 2 hours; monitor thyroid labs.
Clinical use
- Indications: Hyperthyroidism, especially first-trimester pregnancy and thyroid storm.
- Usual dose, route, frequency: 100 to 150 mg PO every 8 hours.
- Maximum dose / adjustments: Titrate to labs; reserved due to liver risk.
Safety
- Contraindications: Severe hepatic disease.
- Black box warning: Risk of severe, sometimes fatal, hepatotoxicity; reserve for situations where methimazole is unsuitable (such as the first trimester).
- Interactions: Same as methimazole.
- Pregnancy / lactation: Preferred antithyroid in the first trimester.
- High-alert: No.
Adverse effects
- Common side effects: Rash, GI upset, arthralgia.
- Serious effects to report: Hepatotoxicity, agranulocytosis (fever, sore throat).
- Antidote / reversal: None; discontinue.
Nursing process
- Assessment before administration: Thyroid labs, LFTs, CBC.
- Interventions during therapy: Multiple daily doses; monitor liver function.
- Monitor: Thyroid labs, LFTs, CBC.
- Evaluation / expected outcome: Controlled hyperthyroidism.
Patient teaching
- Patient teaching: Report fever, sore throat, or jaundice.
- Notify provider if: Yellow skin or eyes, dark urine, fever, sore throat.
- Administration tips: Every 8 hours, consistent timing.