Clindamycin

Clindamycin

Drug monograph · NCLEX study reference
Trade names	Cleocin
Therapeutic class	Antibacterial
Pharmacologic class	Lincosamide
Onset / peak / duration	Rapid; three to four times daily.
Half-life / level	Short; no routine level.
Routes	PO (oral), IV, IM, Topical, Vaginal
High-alert (ISMP)	No
Black box warning	None
Antidote / reversal	Supportive care; treat C. difficile.
Pregnancy / lactation	Used when needed.

Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and must be verified against current manufacturer labeling before clinical use. This is educational content, not prescribing guidance.

Clindamycin (brand name Cleocin) — Antibacterial; Lincosamide.

Identification

• Therapeutic class: Antibacterial.
• Pharmacologic class: Lincosamide.

Pharmacology

• Mechanism of action: Inhibits the 50S ribosomal subunit (bacteriostatic); covers anaerobes and gram-positives.
• Onset / peak / duration: Rapid; three to four times daily.
• Half-life / therapeutic level: Short; no routine level.

Clinical use

• Indications: Skin and soft tissue infections, anaerobic infections, dental infections, aspiration pneumonia, MRSA (some), topical and vaginal for acne and bacterial vaginosis.
• Usual dose, route, frequency: PO, IV, IM, topical, or vaginal.
• Maximum dose / adjustments: Caution in hepatic impairment.

Safety

• Contraindications: Hypersensitivity, prior antibiotic-associated colitis.
• Black box warning: None (the label carries a prominent warning that it can cause severe and potentially fatal C. difficile colitis; reserve for appropriate infections).
• Interactions: Neuromuscular blockers (enhanced), erythromycin (antagonism).
• Pregnancy / lactation: Used when needed.
• High-alert: No.

Adverse effects

• Common side effects: Diarrhea, nausea, rash, metallic taste.
• Serious effects to report: C. difficile colitis (watery or bloody diarrhea), severe rash, hepatotoxicity.
• Antidote / reversal: Supportive care; treat C. difficile.

Nursing process

• Assessment before administration: Allergy, GI and colitis history.
• Interventions during therapy: Take oral with a full glass of water; monitor stools closely.
• Monitor: Stools and signs of colitis, infection resolution.
• Evaluation / expected outcome: Resolution of infection.

Patient teaching

• Patient teaching: Report any significant diarrhea; do not treat the diarrhea with antimotility drugs without guidance.
• Notify provider if: Watery or bloody diarrhea, severe abdominal cramps, rash.
• Administration tips: Full glass of water; complete the course.