Docusate

Docusate

Drug monograph · NCLEX study reference
Trade names	Colace
Therapeutic class	Laxative
Pharmacologic class	Stool softener (surfactant)
Onset / peak / duration	Onset 12 to 72 hours.
Half-life / level	Minimal absorption; no level.
Routes	PO (oral)
High-alert (ISMP)	No
Black box warning	None
Antidote / reversal	Not applicable.
Pregnancy / lactation	Commonly used.

Nursing pharmacology study reference (NCLEX-style monograph). Numeric values are standard teaching ranges for study and must be verified against current manufacturer labeling before clinical use. This is educational content, not prescribing guidance.

Docusate (brand name Colace) — Laxative; Stool softener (surfactant).

Identification

• Therapeutic class: Laxative.
• Pharmacologic class: Stool softener (surfactant).

Pharmacology

• Mechanism of action: Draws water into stool to soften it.
• Onset / peak / duration: Onset 12 to 72 hours.
• Half-life / therapeutic level: Minimal absorption; no level.

Clinical use

• Indications: Prevention of constipation and straining.
• Usual dose, route, frequency: 50 to 300 mg PO daily.
• Maximum dose / adjustments: Per product.

Safety

• Contraindications: Intestinal obstruction, acute abdominal pain.
• Black box warning: None.
• Interactions: May increase absorption of mineral oil.
• Pregnancy / lactation: Commonly used.
• High-alert: No.

Adverse effects

• Common side effects: Mild cramping, throat irritation with liquid.
• Serious effects to report: No bowel movement with abdominal pain.
• Antidote / reversal: Not applicable.

Nursing process

• Assessment before administration: Bowel pattern, hydration.
• Interventions during therapy: Encourage fluids; it softens but does not stimulate.
• Monitor: Bowel movements.
• Evaluation / expected outcome: Softer, easier stools.

Patient teaching

• Patient teaching: Drink plenty of water; for prevention, not rapid relief.
• Notify provider if: No bowel movement, abdominal pain.
• Administration tips: With a full glass of water.